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KMID : 0389420130210020151
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Korean Journal of Stress Research
2013 Volume.21 No. 2 p.151 ~ p.157
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Association of AGT Polymorphisms with Benign Prostate Hyperplasia in Korean Population
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Seok Ho-Sik
Kim Young-Ok
Lee Sang-Hyub
Yoo Koo-Han
Lee Byung-Cheol
Jeon Hye-Sook
Kim Soo-Kang
Chung Joo-Ho
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Abstract
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Most of aging-related disorders are related with stress responses in cellular level. In males after middle age, benign prostate hyperplasia (BPH) may cause severe stress by lower urinary tract symptoms. BPH is common androgenic disorder and family history is an etiological factor. As BPH is a multifactorial disease, many genes and cellular pathways may affect the development. Among them, Angiotensinogen (AGT) was regarded important in vascular diseases. AGT also may affect various diseases throughout whole body organs and polymorphisms of AGT may be associated with aging-related morbidities. AGT and stress genes related to AGT signaling may play a role in the pathophysiology of BPH. However, there was no study of BPH regarding the effect of AGT polymorphisms. In this study, we investigated the association of two AGT single nucleotide polymorphisms (SNPs) (rs699 and rs4762) to the development and clinical features of BPH. A total of 221 BPH subjects and 212 control subjects were analyzed. The BPH patient group was divided into two groups based on each of clinical features [prostate volume, peak urinary flow rate (Qmax), serum prostate specific antigen (PSA) level, and international prostate symptom scores (IPSS)] to analyze the effect of the SNPs on each of clinical parameters. In the result, a missense SNP rs699 was only associated to the development of BPH in the genotypes and allele frequencies (p＜0.05). In conclusion, we suggest that a missense SNP rs699 of AGT may affect the susceptibility to BPH in the Korean population.
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KEYWORD
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Benign prostate hyperplasia, AGT, Single nucleotide polymorphism
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